Abstract :Down syndrome (DS) is popular case which is occurring greatly around the world. In this case the DS child has an extra chromosome (chromosome 21) in its genetic material, to be 47 chromosomes in each body cell, and the phenomenon is called trisomy. The cases vary from mild, moderate or severe. The condition effects on the body shape and the brain development of the baby causing mental delay and physical challenges. DS children suffer from many complications at various ages. External appearance of DS children is very distinguishable, as they have flattened face, Brachycephaly, Almond-shaped eyes, and protruding tongue out of the gaping mouth.